Subject: AD

Envivo Bio, Inc.; Confidential

logo

1.1 Overview of microbial community composition

Figure 1 is an interactive figure showing the microbial community composition in each collected sample. Here, each color and shade corresponds to a different genus. For reference, domestic dogs (Canis familiaris) and gray wolves (Canis lupus) are different species that belong to the same genus (Canis).

You can interact with this figure by:

Figure 1: Microbial community composition of collected saliva and CapScan samples. CapScan samples are ordered from proximal to distal intestine (i.e., increasing distance from mouth). Taxonomic composition is reported at the genus rank. Genera present at <1% relative abundance across all samples are reported as “Other genera”. Note: Blue = Firmicutes; Yellow = Actinomycetes; Green = Bacteroidetes; Red = Proteobacteria; Purple = all other phyla. Shades of the same color (except purple) correspond to different genera from the same phylum.



1.2 High-resolution snapshot of community composition

Figure 2 is an interactive figure showing the microbial community composition at higher taxononomic resolution. Here, each row corresponds to a unique microbe.

You can interact with this figure by:



Figure 2: Heat map showing relative abundance of microbes in each sample (N = 238 total identified). Each row corresponds to a unique microbe and each column corresponds to an individual sample. Note the relative abundance colorscale is in log units.



1.3 Notable microbes detected



1.4 References

Quévrain, E., Maubert, M.A., Michon, C., Chain, F., Marquant, R., Tailhades, J., et al. (2017) Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease. Gut 65: 415–425.

Vogel, V., Bauer, R., Mauerer, S., Schiffelholz, N., Haupt, C., Seibold, G.M., et al. (2021) Angicin, a novel bacteriocin of Streptococcus anginosus. Sci Rep 11: 1–16.

---
title: "<br> Taxonomic profiling of bacterial and archaeal communities from saliva and CapScan-sampled gut metagenomes"
output:
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    df_print: paged
    toc: true
    toc_float: true
  html_notebook: default
  pdf_document: default
---

---

<style>
div.highlight {
background-color: #F2F2F2;
padding: 0px;
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}

</style>

### <b><i>Subject: AD</b></i>
*Envivo Bio, Inc.; Confidential*

```{r setup, include = FALSE}
knitr::opts_chunk$set(echo = TRUE)
```

```{r add logo, echo = FALSE}
logo_path <- "../logo/envivo.svg"

htmltools::img(src = knitr::image_uri(logo_path), 
               alt = "logo", 
               style = "position:absolute; top:0; right:0; padding:10px; width: 145px; height: 42px")
```

```{r load packages, include = FALSE}
# List required packages
cranPackages <- c("BiocManager", "ggplot2", "dplyr", "tidyr",
                  "ape", "ggplot2", "reshape2", "plotly", "heatmaply")
biocPackages <- c("phyloseq", "Biostrings")

# Install missing CRAN packages
installedCRAN <- cranPackages %in% rownames(installed.packages())
if (any(installedCRAN == FALSE)) {
  install.packages(cranPackages[!installedCRAN],
                   repos = 'http://cran.us.r-project.org')
}

# Install missing Bioconductor packages
installedBioc <- biocPackages %in% rownames(installed.packages())
if (any(installedBioc == FALSE)) {
  BiocManager::install(biocPackages[!installedBioc])
}

# Load packages
lapply(c(cranPackages, biocPackages), library, character.only = TRUE)
```

```{r load data, include = FALSE}
# Load CosmosID data and formatted metadata
cosmos <- read.csv(file = "../data/CP04618_cosmosid_20220906.csv")
meta <- read.csv(file = "../data/CP04618_metadata.csv")
```

```{r format data, include = FALSE}
# Prepare tax_table and otu_table objects
tax <- cosmos %>%
  select(Phylum, Class, Order, Family, Genus, Species, Strain) %>%
  as.matrix %>%
  tax_table

start_ind <- grep("Strain", colnames(cosmos))+1
stop_ind <- ncol(cosmos)-2
abundance_scores <- cosmos[,start_ind:stop_ind] %>% otu_table(., taxa_are_rows = TRUE)

# Reformat sample names and metadata sample names so they match
colnames(abundance_scores) <- colnames(abundance_scores) %>%
  gsub("X", "", .) %>%
  gsub("_.*", "", .) %>%
  paste0("EB_", .)

row.names(meta) <- meta %>%
  pull(Sample_number) %>%
  paste0("EB_", .)

sam_data <- sample_data(meta)
```

```{r build phyloseq, include = FALSE}
# Build phyloseq object
ps <- phyloseq(tax, abundance_scores, sam_data)
```

```{r transform data, include = FALSE}
# Log transform
psLog <- ps %>% transform_sample_counts(., function(x) log(x + 1, base = 10))

# Relative abundance transform
psRA <- ps %>% transform_sample_counts(., function(x) x/sum(x)*100)
```

```{r rank phyla, include = FALSE}
phy_rank <- psRA %>%
  tax_glom(., taxrank = "Phylum") %>%
  psmelt %>%
  group_by(Phylum) %>%
  summarise(median = median(Abundance))

phy_rank %>% arrange(desc(median))
```

```{r subject subset, include = FALSE}
# Set subject
subject <- "AD"

# Subset to subject samples and drop missing taxa
psSub <- subset_samples(ps, Subject == subject) %>%
  prune_taxa(taxa_sums(.) > 0, .)

# Add plot label for each sample
sample_data(psSub)$Plot_label <- paste0(sample_names(psSub), " (", sample_data(psSub)$Sample_type, ")")

# Relative abundance transform
psSub_ra <- psSub %>% transform_sample_counts(., function(x) x/sum(x)*100)
```

```{r plot bar, include = FALSE}
# Define NOT IN operator
'%!in%' <- function(x,y)!('%in%'(x,y))

# Agglomerate at Genus and melt
taxrank <- "Genus"
melt <- psSub_ra %>% tax_glom(., taxrank = taxrank) %>% psmelt

# Define major phyla
major_phy <- c("Firmicutes", "Actinobacteria", "Bacteroidetes", "Proteobacteria")

# Identify genera present in <1% relative abundance in all samples
rare_genera <- melt %>%
  group_by(Sample_number, Genus) %>%
  summarize(sum = sum(Abundance)) %>%
  ungroup() %>%
  group_by(Genus) %>%
  summarize(max = max(sum)) %>%
  filter(max < 1) %>%
  pull(Genus)

# Create new column containing name of genus if above cutoff or "Other genera" if not
df <- melt %>%
  mutate(Phy_group = case_when(Phylum %!in% major_phy ~ "Other phylum",
                               TRUE ~ Phylum),
         Phy_group = case_when(Genus %in% rare_genera ~ "Other phylum",
                               TRUE ~ Phy_group),
         Tax_label = case_when(Genus %in% rare_genera ~ "AaOther genera",
                               TRUE ~ Genus)) %>%
  group_by(Subject) %>%
  arrange(Subject, Sample_type)

# Define order
phy_order <- c("Other phylum",
               "Proteobacteria",
               "Bacteroidetes",
               "Actinobacteria",
               "Firmicutes") %>% rev

gen_order <- df %>%
  select(Phy_group, Tax_label) %>%
  mutate(Order = match(Phy_group, phy_order)) %>%
  arrange(Order, desc(Tax_label)) %>%
  distinct %>%
  pull(Tax_label)

gen_order <- factor(gsub("^Aa", "", gen_order), levels = gsub("^Aa", "", gen_order)) # the Aa is to make sure "Other" is plotted at the top

df <- df %>%
  mutate(Tax_label = factor(gsub("^Aa", "", Tax_label), levels = gen_order))

# Define colors
phy_color <- data.frame(Phylum = c("Actinobacteria",
                                   "Other phylum",
                                   "Bacteroidetes",
                                   "Firmicutes",
                                   "Proteobacteria"),
                        Base_color = c("#FFB724",
                                       "#832CFF",
                                       "#64C62A",
                                       "#072AC8",
                                       "#E93B4F"))

phy_color <- phy_color[match(phy_order, phy_color$Phylum),]

# Data frame as input, data frame with new column of hex codes as output
col_palette <- df %>%
  select(Phy_group, Tax_label) %>%
  distinct %>%
  mutate(Hex_code = NA)


for(phy in phy_color$Phylum) {
  test <- col_palette %>%
    filter(Phy_group == phy) %>%
    pull(Tax_label) %>%
    droplevels %>%
    levels
  
  tax.color <- colorRampPalette(c(phy_color$Base_color[match(phy, phy_color$Phylum)], "white"))
  coltest <- tax.color(length(test)+2) %>%
    .[-length(.)]
  col_palette$Hex_code[match(test, col_palette$Tax_label)] <- coltest
}

col_palette <- col_palette %>% arrange(factor(Tax_label, levels = gen_order))
```

<div class="highlight">
### 1.1 Overview of microbial community composition
</div>

Figure 1 is an interactive figure showing the microbial community composition in each collected sample. Here, each color and shade corresponds to a different genus. For reference, domestic dogs (*Canis familiaris*) and gray wolves (*Canis lupus*) are different species that belong to the same genus (*Canis*).
<br><br>
You can interact with this figure by:

* Hovering the cursor over a color in the stacked bar to see the taxonomic identity, sample type, and relative abundance corresponding to that color and bar
* Clicking and dragging the cursor over a portion of the figure to zoom
* Single-clicking a genus's name in the legend to remove that genus from the figure
* Double-clicking (<u>very quickly</u>) a genus's name in the legend to only show that genus
```{r, out.width = "100%", echo = FALSE}
# Plot
pBar <- plot_ly(df, x = ~Plot_label, y = ~Abundance, type = "bar",
             color = ~Tax_label, colors = col_palette$Hex_code,
             textposition = "none",
             text = ~paste("<b>Genus:</b>", Tax_label,
                           "<br><br>", "<b>Sample type:</b>", Sample_type,
                           "<br>", "<b>Relative abundance:</b>", paste0(round(Abundance, digits = 1), "%")),
             hoverinfo = "text") %>%
  layout(xaxis = list(title = "<b>Sample</b>",
                      ticks = "outside"),
         yaxis = list(title = "<b>Relative abundance (%)</b>",
                      ticks = "outside"),
         barmode = "stack",
         font = list(family = "Arial"))

pBar$x$layout$yaxis$linecolor <- "#000000"
pBar
```
**Figure 1:** Microbial community composition of collected saliva and CapScan samples. CapScan samples are ordered from proximal to distal intestine (*i*.*e*., increasing distance from mouth). Taxonomic composition is reported at the genus rank. Genera present at <1% relative abundance across all samples are reported as "Other genera". <u>Note:</u> Blue = *Firmicutes*; Yellow = *Actinomycetes*; Green = *Bacteroidetes*; Red = *Proteobacteria*; Purple = all other phyla. Shades of the same color (except purple) correspond to different genera from the same phylum.

```{r, include = FALSE}
# Ordination-based
pHeat_ord <- plot_heatmap(psSub_ra, method = "NMDS", distance = "bray",
                          taxa.label = "Strain",
                          max.label = 300)

# Retrieve row and taxon orders
row_order <- pHeat_ord$plot_env$taxa.order %>% rev
tax_order <- tax_table(psSub_ra)[match(row_order, rownames(tax_table(psSub_ra))),] %>%
  as.data.frame %>%
  mutate(taxon = rownames(.),
         Abundance = 1,
         Sample = subject)
```

```{r, include = FALSE}
# Prepare data
x <- psSub_ra %>% otu_table %>% as.data.frame
colnames(x) <- lapply(colnames(x), grep, sample_data(psSub_ra)$Plot_label, value = TRUE) %>% unlist

# Add taxonomy
x <- cbind(x, tax_table(psSub_ra))

# Reorder rows and columns to match ordination
x <- x[match(row_order, rownames(x)),]

# Set hovertext
nsamp <- nsamples(psSub_ra)
hover_strain <- x[, 1:nsamp]
hover_strain[] <- paste0("<b>Microbe:</b> ", x$Strain, "\n",
                         "<b>Relative abundance:</b> ")
hover_strain <- as.matrix(hover_strain)

hover_abund <- x[, 1:nsamp] %>% round(., digits = 2) %>% as.data.frame
hover_abund <- apply(hover_abund, 2, paste0, "%")
hover_abund <- as.matrix(hover_abund)

hover_tax <- x[, 1:nsamp]
hover_tax[] <- paste0("\n \n<b>Phylum:</b> ", x$Phylum, "\n",
                   "<b>Class:</b> ", x$Class, "\n",
                   "<b>Order:</b> ", x$Order, "\n",
                   "<b>Family:</b> ", x$Family, "\n",
                   "<b>Genus:</b> ", x$Genus, "\n")
hover_tax <- as.matrix(hover_tax)

hovertext <- matrix(paste0(hover_strain, hover_abund, hover_tax),
                nrow = nrow(hover_tax), ncol = ncol(hover_tax))

# Perform log10 transformation on relative abundances
data <- log(x[, 1:nsamp], base = 10)
data[sapply(data, is.infinite)] <- NA
```
<br><br>

<div class="highlight">
### 1.2 High-resolution snapshot of community composition
</div>
Figure 2 is an interactive figure showing the microbial community composition at higher taxononomic resolution. Here, each row corresponds to a unique microbe.
<br><br>
You can interact with this figure by:

* Hovering the cursor over a cell to see that microbe's genus and species (and strain when available), relative abundance, and full taxonomic classification
* Clicking and dragging the cursor over a portion of the figure to zoom

<br><br>
```{r, out.height = "750px", echo = FALSE}
# Set sample names
#colnames(data) <- c("EB_269 (saliva)", "EB_270 (CapScan)", "EB_271 (CapScan)",
#                    "EB_272 (CapScan)", "EB_273 (CapScan)", "EB_274 (stool)")

# Prepare taxonomy row side
row_side <- x %>% select(Phylum)
row_side$Phylum[row_side$Phylum %!in% major_phy] <- "Other phyla"
row_side$Phylum <- factor(row_side$Phylum, levels = c("Other phyla",
                                                      "Proteobacteria",
                                                      "Bacteroidetes",
                                                      "Actinobacteria",
                                                      "Firmicutes"))

# Plot
pHeat <- heatmaply(data,
                   Rowv = FALSE,
                   Colv = FALSE,
                   colors = viridis::viridis(10),
                   row_side_colors = row_side,
                   row_side_palette = c("Actinobacteria" = "#FFB724",
                                        "Bacteroidetes" = "#64C62A",
                                        "Firmicutes" = "#072AC8",
                                        "Proteobacteria" = "#E93B4F",
                                        "Other phyla" = "#832CFF"),
                   subplot_margin = 0.01,
                   subplot_widths = c(0.9, 0.07),
                   side_color_colorbar_len = 0.3,
                   plot_method = "plotly",
                   custom_hovertext = hovertext,
                   xlab = "<b>Sample</b>",
                   ylab = "<b>Microbe</b>",
                   colorbar_xpos = 1.019,
                   colorbar_ypos = 0.5,
                   colorbar_len = 0.3) %>%
  layout(xaxis = list(showgrid = FALSE),
         yaxis = list(showgrid = FALSE,
                      showticklabels = FALSE),
         font = list(family = "Arial")) %>%
  colorbar(title = "Relative abundance",
           tickvals = c(-1, 0, 1),
           ticktext = c("0.1%", "1%", "10%"))

# Format row side
pHeat$x$layout$xaxis2$ticktext <- "Phylum"
pHeat$x$layout$xaxis$linecolor <- "#000000"
pHeat$x$layout$xaxis2$linecolor <- "#000000"
pHeat$x$layout$yaxis$linecolor <- "#000000"
pHeat$x$layout$legend$yanchor <- "bottom"
pHeat
```
**Figure 2:** Heat map showing relative abundance of microbes in each sample (N = 238 total identified). Each row corresponds to a unique microbe and each column corresponds to an individual sample. Note the relative abundance colorscale is in log units.

<br><br>

<div class="highlight">
### 1.3 Notable microbes detected
</div>

* *Streptococcus anginosus*:
  * Previously shown to produce an antimicrobial protein ("angicin") that disrupts the cell membrane of closely related organisms, giving *Streptococcus anginosus* a competitive advantage (Vogel *et al*., 2021)
  * Second most relatively abundant microbe in proximal CapScan sample (~13%)
<br><br>
* *Faecalibacterium prausnitzii*:
  * Previously shown to produce a small protein that alleviates gut inflammation in mouse models (Quévrain *et al*., 2017)
  * Found at ~4% relative abundance in distal CapScan samples
  
<br><br>

<div class="highlight">
### 1.4 References
</div>

Quévrain, E., Maubert, M.A., Michon, C., Chain, F., Marquant, R., Tailhades, J., *et al*. (2017) Identification of an anti-inflammatory protein from *Faecalibacterium prausnitzii*, a commensal bacterium deficient in Crohn’s disease. Gut 65: 415–425.

Vogel, V., Bauer, R., Mauerer, S., Schiffelholz, N., Haupt, C., Seibold, G.M., *et al*. (2021) Angicin, a novel bacteriocin of *Streptococcus anginosus*. Sci Rep 11: 1–16.